A multiepitope subunit vaccine conveys protection against extraintestinal pathogenic Escherichia coli in mice.

ABSTRACT: Infections due to extraintestinal pathogenic Escherichia coli (ExPEC) are common in humans and animals and include urinary tract infections (from uropathogenic E. coli [UPEC]), septicemia, and wound infections. These infections result in significant morbidity and mortality and in high health care costs. In view of the increasing number of ExPEC infections and the ever-growing antibiotic resistance capability of ExPEC isolates, preventive measures such as an effective vaccine against ExPEC are desirable. An ExPEC vaccine may be cost-effective for select patient groups. Previous vaccine candidates consisted of single target proteins or whole ExPEC cells. Here we describe a subunit vaccine against ExPEC which is based on immunodominant epitopes of the virulence-associated ExPEC proteins FyuA,

SUBMITTER: Wieser A 

PROVIDER: S-EPMC2916271 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature