Allelic diversity among Helicobacter pylori outer membrane protein genes homB and homA generated by recombination.

ABSTRACT: Recombination is one of the main mechanisms contributing to Helicobacter pylori genomic variability. homB and homA are paralogous genes coding for H. pylori outer membrane proteins (OMPs). Both genes display allelic variation yielded by polymorphisms of the genes' middle regions, with six different alleles. This study used bioinformatic and statistical analyses to evaluate whether the allelic diversity of homB and homA is generated by recombination. A detailed molecular analysis of the most prevalent homB allelic variant was also performed to establish its molecular profile. The two most prevalent homB and homA allelic variants resulted from interallelic homologous recombination between the rarest allelic variants of each gene, with a crossover point localized in the middle of the genes, c

SUBMITTER: Oleastro M 

PROVIDER: S-EPMC2916367 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature