Novel florfenicol and chloramphenicol resistance gene discovered in Alaskan soil by using functional metagenomics.

ABSTRACT: Functional metagenomics was used to search for florfenicol resistance genes in libraries of cloned DNA isolated from Alaskan soil. A gene that mediated reduced susceptibility to florfenicol was identified and designated pexA. The predicted PexA protein showed a structure similar to that of efflux pumps of the major facilitator superfamily.

SUBMITTER: Lang KS 

PROVIDER: S-EPMC2916469 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature