Inhibition of HIV fusion with multivalent gold nanoparticles.

ABSTRACT: The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV inhibitor TAK-779, was synthesized and conjugated to 2.0 nm diameter gold nanoparticles. Free SDC-1721 had no inhibitory effect on HIV infection; however, the (SDC-1721)-gold nanoparticle conjugates displayed activity comparable to that of TAK-779. This result suggests that multivalent presentation of small molecules on gold nanoparticle surfaces can convert inactive drugs into potent therapeutics.

SUBMITTER: Bowman MC 

PROVIDER: S-EPMC2916654 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature