The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population.

ABSTRACT:

Background

Epidemiological studies have shown a J- or U-shaped relation between alcohol and type 2 diabetes and coronary heart disease (CHD). The underlying mechanisms are not clear. The aim was to examine the association between alcohol intake and diabetes and intermediate CHD risk factors in relation to selected ADH and ALDH gene variants.

Methodology/principal findings

Cross-sectional study including 6,405 Northern European men and women aged 30-60 years from the general population of Copenhagen, Denmark. Data were collected with self-administered questionnaires, a physical examination, a 2 hour oral glucose tolerance test, and various blood tests. J shaped associations were observed between alcohol and diabetes, metabolic syndrome (MS), systolic and diastolic blood press

SUBMITTER: Husemoen LL 

PROVIDER: S-EPMC2916825 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature