The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia.

ABSTRACT: Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10(-7) or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30 x 10(-11)). This finding was independently replicated in seven studies from East Asia t

SUBMITTER: Hsiung CA 

PROVIDER: S-EPMC2916850 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature