A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals.

ABSTRACT: A protective vaccine against HIV-1 will likely require the elicitation of a broadly neutralizing antibody (bNAb) response. Although the development of an immunogen that elicits such antibodies remains elusive, a proportion of HIV-1 infected individuals evolve broadly neutralizing serum responses over time, demonstrating that the human immune system can recognize and generate NAbs to conserved epitopes on the virus. Understanding the specificities that mediate broad neutralization will provide insight into which epitopes should be targeted for immunogen design and aid in the isolation of broadly neutralizing monoclonal antibodies from these donors. Here, we have used a number of new and established technologies to map the bNAb specificities in the sera of 19 donors who exhibit among the mos

SUBMITTER: Walker LM 

PROVIDER: S-EPMC2916884 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature