Cyclin H expression is increased in GIST with very-high risk of malignancy.

ABSTRACT:

Background

Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R0 resection with small molecule inhibitors is still a controversial issue, since these patients represent a highly heterogeneous population. Therefore, additional prognostic indicators are needed. Here, we evaluated the prognostic value of cyclin H expression in GIST.

Methods

In order to identify prognostic factors of GIST we evaluated a single centre cohort of ninety-five GIST patients. First, GISTs were classified with regard to tumour size, mitotic rate and localisation according to the NIH consensus and to three ad

SUBMITTER: Dorn J 

PROVIDER: S-EPMC2916921 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature