Evolution: a guide to perturb protein function and networks.

ABSTRACT: Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.

SUBMITTER: Lichtarge O 

PROVIDER: S-EPMC2916956 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature