High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.

ABSTRACT:

Introduction

HER2 gene amplification and protein overexpression (HER2+) define a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. Although gene expression profiling has identified an ERBB2 molecular subtype of breast cancer, it is clear that HER2+ tumors reside in all molecular subtypes and represent a genomically and biologically heterogeneous group, needed to be further characterized in large sample sets.

Methods

Genome-wide DNA copy number profiling, using bacterial artificial chromosome (BAC) array comparative genomic hybridization (aCGH), and global gene expression profiling were performed on 200 and 87 HER2+ tumors, respectively. Genomic Identification of Significant Targets in Cancer (GISTIC) was used to identify signif

SUBMITTER: Staaf J 

PROVIDER: S-EPMC2917012 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature