Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

ABSTRACT:

Introduction

Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may well be expressed in a dynamic manner.

Methods

In this study we assessed gene expression changes at multiple time points (days 1, 2, 4, 7, 14) after tamoxifen treatment in the ER-positive ZR-75-1 xenograft model that displays significant changes in apoptosis, proliferation and angiogenesis within 2 days of therapy.

Results

Hierarchical clustering identified six time-related gene expression patterns, which separated into three groups: two with early/transient responses, two with continuous/late responses and t

SUBMITTER: Taylor KJ 

PROVIDER: S-EPMC2917034 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature