Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC2917066 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20100401 4
The biologic and clinical significance of KIT overexpression that associates with KIT gain-of-function mutations occurring in subsets of acute myeloid leukemia (AML) (i.e., core binding factor AML) is unknown. Here, we show that KIT mutations lead to MYC-dependent miR-29b repression and increased levels of the miR-29b target Sp1 in KIT-driven leukemia. Sp1 enhances its own expression by participating in a NFkappaB/HDAC complex that further represses miR-29b transcription. Upregulated Sp1 then bi ...[more]