Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.

ABSTRACT:

Objective

The aim of this study was to quantitate risk and to examine heterogeneity for HLA at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis (JIA), IgM rheumatoid factor-negative polyarticular JIA and oligoarticular JIA. Use of 4-digit comprehensive HLA typing enabled great precision, and a large cohort allowed for consideration of both age at disease onset and disease subtype.

Methods

Polymerase chain reaction-based high-resolution HLA typing for class I and class II loci was accomplished for 820 patients with JIA and 273 control subjects. Specific HLA epitopes, potential interactions of alleles at specific loci and between loci (accounting for linkage disequilibrium and haplotypic associations), and an assessment of the current

SUBMITTER: Hollenbach JA 

PROVIDER: S-EPMC2917207 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature