Deletion of the PER3 gene on chromosome 1p36 in recurrent ER-positive breast cancer.

ABSTRACT:

Purpose

To investigate the role of the PER3 circadian rhythm gene, located within the commonly deleted region of chromosome 1p36, in human breast cancer development.

Patients and methods

The frequency of genetic alterations at 1p36 and PER3 gene copy number status were analyzed in 180 lymph node-negative breast cancers from patients who had received treatment with chemotherapy and/or tamoxifen. The expression levels of PER3 were also analyzed using published microarray profiles from > 400 breast cancer samples. Finally, the effect of loss of Per3 on tumor susceptibility was tested using two mouse models of breast cancer.

Results

Deletion of PER3 is directly related to tumor recurrence in patients with estrogen receptor (ER) - positive breast cancers treated with tamox

SUBMITTER: Climent J 

PROVIDER: S-EPMC2917310 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature