Transcriptome analysis of human cancer reveals a functional role of heme oxygenase-1 in tumor cell adhesion.

ABSTRACT:

Background

Heme Oxygenase-1 (HO-1) is expressed in many cancers and promotes growth and survival of neoplastic cells. Recently, HO-1 has been implicated in tumor cell invasion and metastasis. However, the molecular mechanisms underlying these biologic effects of HO-1 remain largely unknown. To identify a common mechanism of action of HO-1 in cancer, we determined the global effect of HO-1 on the transcriptome of multiple tumor entities and identified a universal HO-1-associated gene expression signature.

Results

Genome-wide expression profiling of Heme Oxygenase-1 expressing versus HO-1 silenced BeWo choriocarcinoma cells as well as a comparative meta-profiling of the preexisting expression database of 190 human tumors of 14 independent cancer types led to the identification

SUBMITTER: Tauber S 

PROVIDER: S-EPMC2917430 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature