Evaluating diabetes and hypertension disease causality using mouse phenotypes.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have found hundreds of single nucleotide polymorphisms (SNPs) associated with common diseases. However, it is largely unknown what genes linked with the SNPs actually implicate disease causality. A definitive proof for disease causality can be demonstration of disease-like phenotypes through genetic perturbation of the genes or alleles, which is obviously a daunting task for complex diseases where only mammalian models can be used.

Results

Here we tapped the rich resource of mouse phenotype data and developed a method to quantify the probability that a gene perturbation causes the phenotypes of a disease. Using type II diabetes (T2D) and hypertension (HT) as study cases, we found that the genes, when perturbed, having high pr

SUBMITTER: Yu H 

PROVIDER: S-EPMC2917432 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature