L-type calcium channel blockers and Parkinson disease in Denmark.

ABSTRACT:

Objective

This study was undertaken to investigate L-type calcium channel blockers of the dihydropyridine class for association with Parkinson disease (PD), because some of these drugs traverse the blood-brain barrier, are potentially neuroprotective, and have previously been evaluated for impact on PD risk.

Methods

We identified 1,931 patients with a first-time diagnosis for PD between 2001 and 2006 as reported in the Danish national hospital/outpatient database and density matched them by birth year and sex to 9,651 controls from the population register. The index date for cases and their corresponding controls was advanced to the date of first recorded prescription for anti-Parkinson drugs, if prior to first PD diagnosis in the hospital records. Prescriptions were determi

SUBMITTER: Ritz B 

PROVIDER: S-EPMC2917467 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature