No association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in Brazilian women.

ABSTRACT: Although oncogenic human papillomavirus (HPV) infections have been established as the necessary cause of cervical cancer, most HPV infections are transient and rarely progress to squamous cervical lesions. The activity of HPV is tightly associated with epithelial cell differentiation; therefore, regulators of differentiation, such as retinoic acid (RA), have been considered targets for the prevention of HPV-associated squamous intraepithelial lesion (SIL) development. The purpose of this study was to determine the association between circulating RA and early events in cervical carcinogenesis, specifically type-specific HPV clearance and SIL detection. Archived blood samples from 643 women participating in the Ludwig-McGill Cohort in São Paulo, Brazil, were analyzed by high-pressure liquid

SUBMITTER: Siegel EM 

PROVIDER: S-EPMC2917513 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature