Differential neuronal vulnerability varies according to specific cardiopulmonary bypass insult in a porcine survival model.

ABSTRACT:

Objective

We investigated whether the degree of vulnerability of different areas in the developing brain varies according to the specific mechanism of the insults caused by cardiopulmonary bypass.

Methods

A meta-analysis of 2 experimental studies (n = 80) was conducted. The end points of the otherwise identical studies were tissue oxygen index in the first experiment, whereas cerebral microvessel vasoconstriction and inflammatory response of endothelial cells were directly visualized in the second study. We assigned ultra-low flow bypass at 25 °C for 60 minutes as control; circulatory arrest at 25 °C for 60 minutes as ischemic stress under circulatory arrest (ischemia-CA); and ultra-low flow bypass at 34 °C for 60 minutes as the stress under ultra-low flow bypass (ischemia-U

SUBMITTER: Ishibashi N 

PROVIDER: S-EPMC2917514 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature