Ontology highlight
ABSTRACT:
SUBMITTER: Renault MA
PROVIDER: S-EPMC2917529 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Renault Marie-Ange MA Roncalli Jérôme J Tongers Jörn J Thorne Tina T Klyachko Ekaterina E Misener Sol S Volpert Olga V OV Mehta Shanu S Burg Aaron A Luedemann Corinne C Qin Gangjian G Kishore Raj R Losordo Douglas W DW
Journal of molecular and cellular cardiology 20100515 3
The morphogen Sonic hedgehog (Shh) promotes neovascularization in adults by inducing pro-angiogenic cytokine expression in fibroblasts; however, the direct effects of Shh on endothelial cell (EC) function during angiogenesis are unknown. Our findings indicate that Shh promotes capillary morphogenesis (tube length on Matrigel increased to 271+/-50% of the length in untreated cells, p=0.00003), induces EC migration (modified Boyden chamber assay, 191+/-35% of migration in untreated cells, p=0.0000 ...[more]