Whole-genome genetic diversity in a sample of Australians with deep Aboriginal ancestry.

ABSTRACT: Australia was probably settled soon after modern humans left Africa, but details of this ancient migration are not well understood. Debate centers on whether the Pleistocene Sahul continent (composed of New Guinea, Australia, and Tasmania) was first settled by a single wave followed by regional divergence into Aboriginal Australian and New Guinean populations (common origin) or whether different parts of the continent were initially populated independently. Australia has been the subject of relatively few DNA studies even though understanding regional variation in genomic structure and diversity will be important if disease-association mapping methods are to be successfully evaluated and applied across populations. We report on a genome-wide investigation of Australian Aboriginal SNP diver

SUBMITTER: McEvoy BP 

PROVIDER: S-EPMC2917718 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature