Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential.

ABSTRACT:

Background

Clinical trials in ischemic patients showed the safety and benefit of autologous bone marrow progenitor cell transplantation. Non-bone marrow progenitor cells with proangiogenic capacities have been described, yet they remain clinically unexploited owing to their scarcity, difficulty of access, and low ex vivo expansibility. We investigated the presence, antigenic profile, expansion capacity, and proangiogenic potential of progenitor cells from the saphenous vein of patients undergoing coronary artery bypass surgery.

Methods and results

CD34-positive cells, negative for the endothelial marker von Willebrand factor, were localized around adventitial vasa vasorum. After dissection of the vein from surrounding tissues and enzymatic digestion, CD34-positive/CD31-negat

SUBMITTER: Campagnolo P 

PROVIDER: S-EPMC2917746 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature