HLA genotyping in the international Type 1 Diabetes Genetics Consortium.

ABSTRACT:

Background

Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loci in all affected sibling pair and trio families, and cases and controls, recruited from four networks worldwide, for analysis with clinical phenotypes and immunological markers.

Purpose

In this article, we present the operational strategy of training, classification, reporting, and quality control of HLA genotyping in four laboratories on three continents over nearly 5 years.

Me

SUBMITTER: Mychaleckyj JC 

PROVIDER: S-EPMC2917849 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature