Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes.

ABSTRACT: Adults maintain tissue-specific stem cells through niche signals. A model for niche function is the Drosophila melanogaster testis, where a small cluster of cells called the hub produce locally available signals that allow only adjacent cells to self-renew. We show here that the principal signalling pathway implicated in this niche, chemokine activation of STAT, does not primarily regulate self-renewal of germline stem cells (GSCs), but rather governs GSC adhesion to hub cells. In fact, GSC renewal does not require hub cell contact, as GSCs can be renewed solely by contact with the second resident stem cell population, somatic cyst stem cells (CySCs), and this involves BMP signalling. These data suggest a modified paradigm whereby the hub cells function as architects of the stem cell envir

SUBMITTER: Leatherman JL 

PROVIDER: S-EPMC2917891 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature