Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.

ABSTRACT:

Unlabelled

Osteoporosis is a major public health problem characterized by low bone mineral density (BMD). This replication study confirmed 38 single-nucleotide polymorphisms (SNPs) out of 139 SNPs previously reported in three recent genome-wide association studies (GWASs) in an independent US white sample. Ten SNPs achieved combined p < 3.6 x 10(-4).

Introduction

BMD is under strong genetic control. This study aims to verify the potential associations between BMD and candidate genes/loci reported by GWAS of FHS100K, Icelandic deCODE, and UK-NL.

Methods

Eight promising (at the genome-wide significant level after Bonferroni correction) and 131 available sub-promising (at the most stringent p value, p < 5.5 x 10(-5) in the three GWASs reports) SNPs were selected. By usin

SUBMITTER: Zhang YP 

PROVIDER: S-EPMC2917903 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature