Newly diagnosed diabetes mellitus as a risk factor for serious liver disease.

ABSTRACT:

Background

The negative impact of diabetes mellitus is well recognized, yet little is known about the effect of this disease on the liver, an organ susceptible to nonalcoholic fatty liver disease related to insulin resistance. We evaluated whether adults with newly diagnosed diabetes were at increased risk of serious liver disease.

Methods

We used administrative health databases for the province of Ontario (1994-2006) to perform a population-based matched retrospective cohort study. The exposed group comprised 438 069 adults with newly diagnosed diabetes. The unexposed comparison group--those without known diabetes--consisted of 2 059 708 individuals, matched 5:1 to exposed persons, by birth year, sex and local health region. We excluded individuals with pre-existing liver o

SUBMITTER: Porepa L 

PROVIDER: S-EPMC2917963 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature