Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.

ABSTRACT: Despite implementation of CDC recommendations and bundled interventions for preventing catheter-associated blood stream infection, ventilator-associated pneumonia, or urinary catheter-associated infections, nosocomial infections and sepsis remain a significant cause of morbidity and mortality in critically ill children. Recent studies suggest that acquired critical illness stress-induced immune suppression (CRISIS) plays a role in the development of nosocomial infection and sepsis. This condition can be related to inadequate zinc, selenium, and glutamine levels, as well as hypoprolactinemia, leading to stress-induced lymphopenia, a predominant T(H)2 monocyte/macrophage state, and subsequent immune suppression. Prolonged immune dysfunction increases the likelihood of nosocomial infections a

SUBMITTER: Carcillo J 

PROVIDER: S-EPMC2918276 | biostudies-literature | 2009 Jul-Aug

REPOSITORIES: biostudies-literature