Synovial fluid proteins differentiate between the subtypes of juvenile idiopathic arthritis.

ABSTRACT:

Objective

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of inflammatory diseases, and no clinically useful prognostic markers to predict disease outcome in children with JIA are currently available. Synovial fluid likely reflects the proteins present in the inflamed synovium. The purpose of this study was to delineate the synovial fluid proteome and determine whether protein expression differs in the different subtypes of JIA.

Methods

Synovial fluid samples obtained from children with oligoarticular JIA, polyarticular JIA, or systemic JIA were compared. Two-dimensional gel electrophoresis for protein separation and matrix-assisted laser desorption ionization-time-of-flight mass spectrometry and quadripole time-of-flight mass spectrometry for protein identifica

SUBMITTER: Rosenkranz ME 

PROVIDER: S-EPMC2918379 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature