Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus.

ABSTRACT:

Objective

A genome-wide association study (GWAS) in the Japanese population identified 2 new Parkinson disease (PD) susceptibility loci on 1q32 (PARK16) (OMIM 613164) and BST1. We analyzed single nucleotide polymorphism (SNPs) located at the GWAS-linked loci (PARK16, PARK8, PARK1, and BST1) in a Chinese population and also conducted a meta-analysis in Asians by pooling 2 independent replication studies from Japan.

Methods

We conducted an analysis of 13 SNPs associated with PD GWAS-linked loci in 2 case-control cohorts comprised of 1,349 ethnic Chinese subjects.

Results

PARK16, PARK8, and PARK1 loci but not BST1 were found to be associated with PD. PARK16 SNPs were associated with a decreased risk while PARK1 and PARK8 SNPs were associated with an increased risk of PD.

SUBMITTER: Tan EK 

PROVIDER: S-EPMC2918477 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature