Sox6 is necessary for efficient erythropoiesis in adult mice under physiological and anemia-induced stress conditions.

ABSTRACT:

Background

Definitive erythropoiesis is a vital process throughout life. Both its basal activity under physiological conditions and its increased activity under anemia-induced stress conditions are highly stimulated by the hormone erythropoietin. The transcription factor Sox6 was previously shown to enhance fetal erythropoiesis together and beyond erythropoietin signaling, but its importance in adulthood and mechanisms of action remain unknown. We used here Sox6 conditional null mice and molecular assays to address these questions.

Methodology/principal findings

Sox6fl/flErGFPCre adult mice, which lacked Sox6 in erythroid cells, exhibited compensated anemia, erythroid cell developmental defects, and anisocytotic, short-lived red cells under physiological conditions, proving

SUBMITTER: Dumitriu B 

PROVIDER: S-EPMC2918505 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature