FOXP2 gene and language impairment in schizophrenia: association and epigenetic studies.

ABSTRACT:

Background

Schizophrenia is considered a language related human specific disease. Previous studies have reported evidence of positive selection for schizophrenia-associated genes specific to the human lineage. FOXP2 shows two important features as a convincing candidate gene for schizophrenia vulnerability: FOXP2 is the first gene related to a language disorder, and it has been subject to positive selection in the human lineage.

Methods

Twenty-seven SNPs of FOXP2 were genotyped in a cohort of 293 patients with schizophrenia and 340 controls. We analyzed in particular the association with the poverty of speech and the intensity of auditory hallucinations. Potential expansion of three trinucleotide repeats of FOXP2 was also screened in a subsample. Methylation analysis of a Cp

SUBMITTER: Tolosa A 

PROVIDER: S-EPMC2918571 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature