Induction of early Purkinje cell dendritic differentiation by thyroid hormone requires RORα.

ABSTRACT:

Background

The active form (T3) of thyroid hormone (TH) controls critical aspects of cerebellar development, such as migration of postmitotic neurons and terminal dendritic differentiation of Purkinje cells. The effects of T3 on early dendritic differentiation are poorly understood.

Results

In this study, we have analyzed the influence of T3 on the progression of the early steps of Purkinje cell dendritic differentiation in postnatal day 0 organotypic cerebellar cultures. These steps include, successively, regression of immature neuritic processes, a stellate cell stage, and the extension of several long and mature perisomatic protrusions before the growth of the ultimate dendritic tree. We also studied the involvement of RORalpha, a nuclear receptor controlling early Purkin

SUBMITTER: Boukhtouche F 

PROVIDER: S-EPMC2918593 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature