Body size, IGF and growth hormone polymorphisms, and colorectal adenomas and hyperplastic polyps.

ABSTRACT:

Objective

We examined the risk of colorectal polyps in relation to body size factors and candidate polymorphisms in selected genes of insulin-like growth factor (IGF1) (rs5742612), IGF1 receptor (IGF1R) (rs2229765), IGF binding protein 3 (IGFBP3) (rs2854746) and growth hormone (GH1) (rs2665802).

Design

Cases with colorectal adenomas (n=519), hyperplastic polyps (n=691), or both lesions (n=227), and controls (n=772), aged 20-74 years, were recruited from patients who underwent colonoscopy between December 2004 and September 2007 at a large integrated-health plan in Washington state. Subjects participated in a 45-minute telephone interview to ascertain body size and physical activity, and provided a buccal DNA sample for genetic analysis. Odds ratios (OR) and 95% confidence in

SUBMITTER: Wernli KJ 

PROVIDER: S-EPMC2918710 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature