Cortical neuroanatomic correlates of symptom severity in primary progressive aphasia.

ABSTRACT:

Objective

To test the validity and reliability of a new measure of clinical impairment in primary progressive aphasia (PPA), the Progressive Aphasia Severity Scale (PASS), and to investigate relationships with MRI-based cortical thickness biomarkers for localizing and quantifying the severity of anatomic abnormalities.

Methods

Patients with PPA were rated using the PASS and underwent performance-based language testing and MRI scans that were processed for cortical thickness measures.

Results

The level of impairment in PASS fluency, syntax/grammar, and word comprehension showed strong specific correlations with performance-based measures of these domains of language, and demonstrated high interrater reliability. Left inferior frontal thinning correlated with impairment

SUBMITTER: Sapolsky D 

PROVIDER: S-EPMC2918888 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature