Novelty seeking and introversion do not predict the long-term risk of Parkinson disease.

ABSTRACT:

Objective

It has been suggested that people who develop Parkinson disease (PD) may have a characteristic premorbid personality. We tested this hypothesis using a large historical cohort study with long follow-up.

Methods

We conducted a historical cohort study in the region including the 120-mile radius centered in Rochester, MN. We recruited 7,216 subjects who completed the Minnesota Multiphasic Personality Inventory (MMPI) for research at the Mayo Clinic from 1962 through 1965 and we considered 5 MMPI scales to measure sensation seeking, hypomania, positive emotionality, social introversion, and constraint. A total of 6,822 subjects (94.5% of the baseline sample) were followed over 4 decades either actively (via interview and examination) or passively (via medical records).

SUBMITTER: Arabia G 

PROVIDER: S-EPMC2918889 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature