Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.

ABSTRACT:

Context

Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department.

Objective

To test the hypothesis of noninferiority between lactate clearance and central venous oxygen saturation (ScvO2) as goals of early sepsis resuscitation.

Design, setting, and patients

Multicenter randomized, noninferiority trial involving patients with severe sepsis and evidence of hypoperfusion or septic shock who were admitted to the emergency department from January 2007 to January 2009 at 1 of 3 participating US urban hospitals.

Interventions

We randomly assigned patients to 1 of 2 resuscitation protocols. The ScvO2 group was resuscitated to normalize central venous pressure, mean arterial pressure, a

SUBMITTER: Jones AE 

PROVIDER: S-EPMC2918907 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature