Cellular and molecular remodeling of the endocytic pathway during differentiation of Trypanosoma brucei bloodstream forms.

ABSTRACT: During the course of mammalian infection, African trypanosomes undergo extensive cellular differentiation, as actively dividing long slender (SL) forms progressively transform into intermediate (I) forms and finally quiescent G(1)/G(0)-locked short stumpy (ST) forms. ST forms maintain adaptations compatible with their survival in the mammalian bloodstream, such as high endocytic activity, but they already show preadaptations to the insect midgut conditions. The nutritional requirements of ST forms must differ from those of SL forms because the ST forms stop multiplying. We report that the uptake of several ligands was reduced in ST forms compared with that in SL forms. In particular, the haptoglobin-hemoglobin (Hp-Hb) complex was no longer taken up due to dramatic downregulation of its cog

SUBMITTER: Vanhollebeke B 

PROVIDER: S-EPMC2918936 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature