Distribution in tissue and seasonal variation of norovirus genogroup I and II ligands in oysters.

ABSTRACT: Bivalve molluscan shellfish, such as oysters, filter large volumes of water as part of their feeding activities and are able to accumulate and concentrate different types of pathogens, particularly noroviruses, from fecal human pollution. Based on our previous observation of a specific binding of the Norwalk strain (prototype norovirus genogroup I) to the oyster digestive tract through an A-like carbohydrate structure indistinguishable from human blood group A antigen and on the large diversity between strains in terms of carbohydrate-binding specificities, we evaluated the different ligands implicated in attachment to oysters tissues of strains representative of two main genogroups of human norovirus. The GI.1 and GII.4 strains differed in that the latter recognized a sialic acid-containi

SUBMITTER: Maalouf H 

PROVIDER: S-EPMC2918968 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature