Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents.

ABSTRACT:

Objective

As the use of atypical antipsychotics in children and adolescents has increased, concerns have been raised about their long-term safety. We aimed to investigate the association between risperidone-induced weight gain, leptin concentration, and the leptin gene (LEP) -2548G/A variants in youths.

Methods

Medically healthy 7- to 17-year-old children and adolescents, in extended naturalistic treatment with risperidone, were recruited through pediatric psychiatry clinics. Anthropometric measures and laboratory testing were conducted. Growth and medication history was obtained from the medical record. The effect of the LEP genotypes on leptin concentration and on the slopes of the weight and body mass index (BMI) Z-score curves before and after the onset of risperidone tr

SUBMITTER: Calarge CA 

PROVIDER: S-EPMC2919234 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature