Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.

ABSTRACT: Primary cilia are required for signaling, chemosensing and mechanosensing in many fluid-filled organs, thus cilia could also have a direct role in heart development. They are essential to the development of cardiac left-right (LR) asymmetry by means of their function at the embryonic organizer (node). We show that cilia are found in the mouse embryo heart at embryonic day (e) 9.5-e12.5. We demonstrate abnormal development of the endocardial cushions (ECCs) and compact myocardium (CM) in e9.5 mouse embryos with absent cilia. In contrast, hearts from embryos with abnormal LR development due to paralyzed, but structurally normal, node cilia show less severe ECC defects and normal CM. These observations suggest that a subset of cilia called cardiac cilia are required in cardiac development ind

SUBMITTER: Slough J 

PROVIDER: S-EPMC2919240 | biostudies-literature | 2008 Sep

REPOSITORIES: biostudies-literature