The expression of vasoactive intestinal peptide receptor 1 is negatively modulated by microRNA 525-5p.

ABSTRACT:

Background

The human Vasoactive Intestinal Peptide (VIP) is a neurokine with effects on the immune system where it is involved in promoting tolerance. In this context, one of its receptors, VPAC1, has been found to be down-modulated in cells of the immune network in response to activating stimuli. In particular, the bacterial liposaccharide (LPS), a strong activator of the innate immune system, induces a rapid decrease of VPAC1 expression in monocytes and this event correlates with polymorphisms in the 3'-UTR of the gene.

Methodology/principal findings

MicroRNA 525-5p, having as putative target the 3'-UTR region of VPAC1, has been analysed for its expression in monocytes and for its role in down-modulating VPAC1 expression. We report here that miR-525-5p is promptly up-regul

SUBMITTER: Cocco E 

PROVIDER: S-EPMC2919398 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature