Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies.

ABSTRACT: Over the past decade malaria intervention coverage has been scaled up across Africa. However, it remains unclear what overall reduction in transmission is achievable using currently available tools. We developed an individual-based simulation model for Plasmodium falciparum transmission in an African context incorporating the three major vector species (Anopheles gambiae s.s., An. arabiensis, and An. funestus) with parameters obtained by fitting to parasite prevalence data from 34 transmission settings across Africa. We incorporated the effect of the switch to artemisinin-combination therapy (ACT) and increasing coverage of long-lasting insecticide treated nets (LLINs) from the year 2000 onwards. We then explored the impact on transmission of continued roll-out of LLINs, additional rounds

SUBMITTER: Griffin JT 

PROVIDER: S-EPMC2919425 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature