Characterization of two Runx1-dependent nociceptor differentiation programs necessary for inflammatory versus neuropathic pain.

ABSTRACT:

Background

The cellular and molecular programs that control specific types of pain are poorly understood. We reported previously that the runt domain transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron phenotypes necessary for inflammatory and neuropathic pain.

Results

Here we show that expression of Runx1-dependent ion channels and receptors is distributed into two nociceptor populations that are distinguished by persistent or transient Runx1 expression. Conditional mutation of Runx1 at perinatal stages leads to preferential impairment of Runx1-persistent nociceptors and a selective defect in inflammatory pain. Conversely, constitutive Runx1 expression in Runx1-transient nociceptors leads to an impairment of Runx1-transient noci

SUBMITTER: Abdel Samad O 

PROVIDER: S-EPMC2919460 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature