Dataset Information
Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus.
Ontology highlight
ABSTRACT: Background
Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.Methods
We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls.Results
NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps major and the left anterior corona radiata.Conclusions
Several possible mechanisms of white matter injury are explored, including vascular injury, medication effects, and platelet or fibrin macro- or microembolism from Libman-Sacks endocarditis.
SUBMITTER: Jung RE
PROVIDER: S-EPMC2919505 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Publications
Diffusion tensor imaging in neuropsychiatric systemic lupus erythematosus.
BMC neurology 20100728
<h4>Background</h4>Neuropsychiatric systemic lupus erythematosus (NPSLE) is associated with increased morbidity and mortality.<h4>Methods</h4>We used Diffusion Tensor Imaging (DTI) to assess white matter abnormalities in seventeen NPSLE patients, sixteen SLE patients without NPSLE, and twenty age- and gender-matched controls.<h4>Results</h4>NPSLE patients differed significantly from SLE and control patients in white matter integrity of the body of the corpus callosum, the left arm of the forceps ...[more]
