Elevated systemic levels of inflammatory cytokines in older women with persistent cervical human papillomavirus infection.

ABSTRACT:

Background

Defects in lymphoproliferative responses to mitogens/antigens in women >45 years old with a persistent type-specific human papillomavirus (HPV) infection have been reported.

Methods

To determine whether these defects were associated with altered cytokine profiles, plasma and peripheral blood mononuclear cell (PBMC) culture supernatants from 50 cases (oversampled for their reduced lymphoproliferative ability) and 50 uninfected controls (oversampled for their robust lymphoproliferative ability) were examined for 24 cytokines using multiplexed bead-based immunoassays and ELISA.

Results

The following plasma cytokines were significantly increased in cases relative to controls (cases versus controls; median pg/mL): interleukin (IL)-6, 393.1 versus 14.5; IL-8, 1,1

SUBMITTER: Kemp TJ 

PROVIDER: S-EPMC2919599 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature