Exercise without weight loss does not reduce C-reactive protein: the INFLAME study.

ABSTRACT:

Purpose

Numerous cross-sectional studies have observed an inverse association between C-reactive protein (CRP) and physical activity. Exercise training trials have produced conflicting results, but none of these studies was specifically designed to examine CRP. The objective of the Inflammation and Exercise (INFLAME) study was to examine whether aerobic exercise training without dietary intervention can reduce CRP in individuals with elevated CRP.

Methods

The study was a randomized controlled trial of 162 sedentary men and women with elevated CRP (> or = 2.0 mg·L(-1)). Participants were randomized into a nonexercise control group or an exercise group that trained for 4 months. The primary outcome was change in CRP.

Results

The study participants had a mean (SD) age of

SUBMITTER: Church TS 

PROVIDER: S-EPMC2919641 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature