Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.

ABSTRACT:

Objective

The aim of this study is to discover common variants in 6 lipid metabolic genes and construct and validate a genetic risk score (GRS) based on the joint effects of genetic variants in multiple genes from lipid and other pathobiologic pathways.

Background

Explaining the genetic basis of coronary artery disease (CAD) is incomplete. Discovery and aggregation of genetic variants from multiple pathways may advance this objective.

Methods

Premature CAD cases (n = 1,947) and CAD-free controls (n = 1,036) were selected from our angiographic registry. In a discovery phase, single nucleotide polymorphisms (SNPs) at 56 loci from internal discovery and external reports were tested for associations with biomarkers and CAD: 28 promising SNPs were then tested jointly for C

SUBMITTER: Anderson JL 

PROVIDER: S-EPMC2919893 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature