Hereditary hemochromatosis (HFE) genotypes in heart failure: relation to etiology and prognosis.

ABSTRACT:

Background

It is believed that hereditary hemochromatosis (HH) might play a role in cardiac disease (heart failure (HF) and ischemia). Mutations within several genes are HH-associated, the most common being the HFE gene. In a large cohort of HF patients, we sought to determine the etiological role and the prognostic significance of HFE genotypes.

Methods

We studied 667 HF patients (72.7% men) with depressed systolic function, enrolled in a multicentre trial with a follow-up period of up to 5 years. All were genotyped for the known HFE variants C282Y, H63D and S65C.

Results

The genotype and allele frequencies in the HF group were similar to the frequencies determined in the general Danish population. In multivariable analysis mortality was not predicted by C282Y-carrie

SUBMITTER: Moller DV 

PROVIDER: S-EPMC2920247 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature