A case-control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population.

ABSTRACT:

Background

Glucose-dependent insulinotropic polypeptide (GIP) is one of the incretins, which plays a crucial role in the secretion of insulin upon food stimulus and in the regulation of postprandial glucose level. It also exerts an effect on the synthesis and secretion of lipoprotein lipase, from adipocytes, important for lipid metabolism. The aim of our study was to do a case-control association analysis of common variants in GIP in association with type 2 diabetes and related biochemical parameters.

Method

A total of 2000 subjects which includes 1000 (584M/416F) cases with type 2 diabetes and 1000 (470M/530F) normoglycemic control subjects belonging to Dravidian ethnicity from South India were recruited to assess the effect of single nucleotide polymorphisms (SNPs) in GIP

SUBMITTER: Sugunan D 

PROVIDER: S-EPMC2920866 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature