KeaA, a Dictyostelium Kelch-domain protein that regulates the response to stress and development.

ABSTRACT:

Background

The protein kinase YakA is responsible for the growth arrest and induction of developmental processes that occur upon starvation of Dictyostelium cells. yakA- cells are aggregation deficient, have a faster cell cycle and are hypersensitive to oxidative and nitrosoative stress. With the aim of isolating members of the YakA pathway, suppressors of the death induced by nitrosoative stress in the yakA- cells were identified. One of the suppressor mutations occurred in keaA, a gene identical to DG1106 and similar to Keap1 from mice and the Kelch protein from Drosophila, among others that contain Kelch domains.

Results

A mutation in keaA suppresses the hypersensitivity to oxidative and nitrosoative stresses but not the faster growth phenotype of yakA- cells. The growth

SUBMITTER: Mantzouranis L 

PROVIDER: S-EPMC2920877 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature